Human and animals continuously select important stimuli, in expense of ignoring others, to orient their gaze and attention. Several interconnected cortical and subcortical areas are involved in target selection. The midbrain gaze circuitry is a well-studied structure that is involved in target selection for attention and eye movement. I will discuss how midbrain circuitry processes sensory inputs to select the next location for eye movements. Moreover, I will present empirical evidences about a synaptic machinery that mediates integration of top-down and sensory-driven signals to guide eye movements.